Simparica Trio 44.1-88 lbs Dogs, 6 Month Supply

Simparica Trio
Regular Price:Crossed Out$228.86Your Price:$171.65
E PAW Price:  $154.45

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This product requires a prescription

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2. We’ll verify your prescription and ship your order.

Details and state availability.

Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets)

is a flavored, chewable tablet for administration to dogs 8 weeks of age and older.

Simparica Trio for dogs is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections.

Simparica Trio kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black?legged tick), and Rhipicephalus sanguineus (brown dog tick) for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater.

We proudly ensure that our products are obtained directly from the manufacturer or their authorized distributor, guaranteeing their authenticity and backed by the manufacturer themselves.

See all Simparica Trio Dosages

Our pharmacists are available for counseling regarding prescriptions purchased from PetPawsRx before and after dispensing. Monday - Friday, 9 AM - 2 PM CST. 1-800-367-4444.

Customer Reviews

Based on 52 reviews

Customers say

AI-generated from customer reviews.

Simparica Trio offers protection against heartworm disease, ticks, fleas, roundworms, and hookworms for dogs weighing 44.1-88 lbs. Customers appreciate the fast shipping and great prices, along with the helpful customer service.

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  • Andrew C.
    Verified Buyer

    Great price on solid product!

    Great price on solid product! Will use PetPaws again for sure.

    Published date
    07/15/26
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  • Kimberly A.
    Verified Buyer

    Simparico Trio

    Arrived on time and nicely packaged

    Published date
    07/07/26
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  • Sara C.
    Verified Buyer

    Works well!

    Well I don’t personally take it but my dogs seem to do well on it. The price at this site is the reason we keep coming back!

    Published date
    06/26/26
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  • Gene G.
    Verified Buyer

    The Best Ever

    Sold for way more in other Vet clinics, your prices are unbeatable. Thanks again

    Published date
    06/24/26
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  • Cynthia H.
    Verified Buyer

    Simparica Trio

    Services are quick and professional

    Published date
    06/22/26
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  • Amber W.
    Verified Buyer

    Great customer service

    Customer service is fantastic and product was delivered quickly at a better price than most places

    Published date
    05/27/26
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  • Martine E.
    Verified Buyer

    Convenient and works

    I have used Simparica Trio on 3 different dogs over the past few years. I have never had a problem with fleas, ticks, or heartworms. The single pill vs a HW pill and liquid protection is so convenient. Each dog thought of it as a treat, so must be tasty too.

    Published date
    05/26/26
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  • LaCaze
    Verified Buyer

    My dog's meds

    This online pet Pharmacy is by far the cheapest place I found to get my dog's prescriptions from, now I will point out that actually getting the purchased products does take a little longer than normal, so expect to have a delay in shipping for your order, but, other than that, I will definitely be ...

    Published date
    05/25/26
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